Antiaging

Scientists have discovered a new contender in the quest to hack the human aging process, and it’s a little-studied protein within a cell structure that also doesn’t get a lot of airtime in research despite being one of the first organelles identified more than a century ago.The Golgi apparatus, also known as the Golgi body and Golgi complex (much to the chagrin of biology students the world over), is an odd-looking organelle resembling folded pasta sheets or layers of icing. But it has an important role within complex…

Researchers have utilized AI to discover new senolytic compounds that can suppress age-related processes, such as cancer and inflammation. By training deep neural networks on experimental data, they were able to identify three potent drug candidates from a chemical pool of over 800,000 molecules, promising superior clinical properties to existing senolytics.New platform holds the promise to drive progress in the development of senolytic anti-aging compounds and research on longevity.A recent paper published in Nature…

Finding new drugs – called "drug discovery" – is an expensive and time-consuming task. But a type of artificial intelligence called machine learning can massively accelerate the process and do the job for a fraction of the price.My colleagues and I recently used this technology to find three promising candidates for senolytic drugs – drugs that slow ageing and prevent age-related diseases.Senolytics work by killing senescent cells. These are cells that are "alive" (metabolically active), but which can no longer…

More than 30 years after it was identified as a key ‘longevity gene,’ the protein klotho has been used to boost the cognitive function of aging rhesus macaques, paving the way for human trials.Following on from recent mice models, an international team of scientists found that the working memory and task-completion abilities of 18 rhesus macaques (Macaca mulatta), aged an average of 22 years (the human-equivalent of around 65), was boosted when injected with the klotho protein.The researchers include scientists from the…

Lauren Goode: So it's not at the point yet where you have a control group of say Great Danes or rottweilers, and one group is on the drugs and they've lived longer, and another group is not on the drugs or they're using a placebo and they had shorter lives. It's that you're looking at specific biomarkers around health span, and so far, some of the evidence is suggesting that there's greater health or anti-aging in the dogs that are on the drugs?Celine Halioua: Yeah. I wouldn't call it anti-aging. I would call it, we've…

It’s not every day that police storm through the doors of a scientific session and eject half the audience. But that’s what happened on Friday at the Boston Convention and Exhibition Center during a round of scientific presentations featuring Juan Carlos Izpisua Belmonte, a specialist in “rejuvenation” technology at a secretive, wealthy, anti-aging startup called Altos Labs.Police ordered anyone without a seat to clear out, after an overflow crowd began jostling in the aisles for space and violating the building’s fire…

Researchers have used a machine learning model to identify three compounds that could combat aging. They say their approach could be an effective way of identifying new drugs, especially for complex diseases.Cell division is necessary for our body to grow and for tissues to renew themselves. Cellular senescence describes the phenomenon where cells permanently stop dividing but remain in the body, causing tissue damage and aging across body organs and systems.Ordinarily, senescent cells are cleared from the body by our…

Cocklebur extracts, derived from the fruit of a plant often considered a noxious weed, have shown potential in protecting skin, accelerating wound healing, and combating wrinkles due to their antioxidant and anti-inflammatory properties. Researchers discovered that these extracts reduced UVB damage and promoted wound healing in laboratory tests while also influencing collagen production, which maintains skin elasticity. The findings suggest that cocklebur could be a valuable ingredient in cosmetic products, especially…

However, it is important to note that the researchers do not recommend taking this drug as there are some side effects.Researchers in New Zealand have discovered a drug that has the potential for longer and healthier aging.An Aotearoa New Zealand study, recently published in the renowned journal Nature Aging, has advanced the timeless pursuit of immortality.The University of Auckland’s Waipapa Taumata Rau trial shows that administering a cancer treatment drug to healthy middle-aged mice (one year) for a prolonged period…

Heart failure is a medical condition in which the heart cannot pump enough blood to meet the body’s needs. It can result from a variety of factors, including heart disease, high blood pressure, and heart valve problems.A breakthrough offers a potential target for treating heart failure patients.An anti-aging gene found in centenarians has been shown to reverse the heart’s biological age by 10 years. This groundbreaking discovery, published in the journal Cardiovascular Research and led by scientists from the University of…