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Existing drug aids stroke recovery by rewiring undamaged neurons

Most treatments for strokes aim to help reduce or repair damage to affected neurons. But a new study in mice has shown that a drug already in use to treat certain neurological disorders could help patients recover from strokes by getting undamaged neurons to pick up the slack.An ischemic stroke occurs when a blood vessel blockage interrupts blood flow to the brain, causing neurons to die off. Survivors can suffer impaired fine motor control and speech, and other disabilities, for which long-term rehabilitation is often…

First Patient Injected With Experimental Cancer-Killing Virus in New Clinical Trial

An experimental cancer-killing virus has been administered to a human patient for the first time, with hopes the testing will ultimately reveal evidence of a new means of successfully fighting cancer tumors in people's bodies.  The drug candidate, called CF33-hNIS (aka Vaxinia), is what's called an oncolytic virus, a genetically modified virus designed to selectively infect and kill cancer cells while sparing healthy ones.In the case of CF33-hNIS, the modified pox virus works by entering cells and duplicating itself.…

Why the FDA rejected fluvoxamine as a Covid-19 drug

Last year, researchers who were testing cheap generic drugs in the hope that one or more of them might prove to work as a Covid-19 treatment stumbled across a promising candidate: the antidepressant fluvoxamine. In a massive randomized controlled trial, called Together, researchers at McMaster University compared eight different repurposed drugs, and found most of them — including ivermectin, the antiparasitic that many embraced as a Covid-19 miracle cure — failed to do much against the disease. But fluvoxamine…

Johnny Depp trial: Actor’s childhood friend says Marilyn Manson isn’t to blame for his drug use

Johnny Depp’s former long-time friend Bruce Witkin testified on Thursday (19 May) that Marilyn Manson isn’t to blame for the Pirates actor’s drug use.While on the stand, Depp – who was briefly married to Witkin’s sister-in-law Lori Anne Allison – claimed he once gave Manson a pill to stop him from talking so much.Depp’s admission was part of his testimony in the $50m defamation lawsuit he filed against ex-wife Amber Heard. The actor claims Heard’s 2018 op-ed in The Washington Post, implying he abused her, has adversely…

New cataract-clearing drug shows promise in tests in mice

Cataracts are one of the most common forms of vision impairment, and unfortunately surgery is the only real treatment. But the clouds may be parting on a new drug treatment, improving the vision of the majority of mice it was tested on.Cataracts occur as clumps of proteins that form on the lens of the eye, appearing as a cloudy area that can impair vision. They usually develop slowly with age, and if they get bad enough they can only be treated by surgically removing the lens and replacing it with a clear artificial…

‘Smart’ Contact Lens Could Help Treat a Leading Cause of Blindness, Scientists Say

A flexible contact lens that senses eye pressure and releases a drug on-demand could help treat glaucoma, the second leading global cause of blindness worldwide.The compact wireless device, which has been developed by a team of Chinese researchers and tested in pig and rabbit eyes so far, appears to detect and reduce rising eye pressure, one of the usual causes of glaucoma.  Glaucoma is an umbrella term for a group of eye diseases where damage to the optic nerve, which relays visual information to the brain, causes…

Orioles’ Matt Harvey suspended 60 games for drug distribution

Article content Major League Baseball announced Tuesday the suspension of Baltimore Orioles pitcher Matt Harvey for 60 games without pay for “participating in the distribution of a prohibited Drug of Abuse” in violation of the league’s drug policy. Article content The start date of Harvey’s suspension is retroactive to April 29, making him eligible to return in late June. Harvey was one of four players to testify in federal court in February that former Los Angeles Angels communications director Eric Kay provided…

Jackass star Bam Margera completes one-year drug and alcohol treatment programme

Bam Margera has completed a year-long drug and alcohol treatment programme.The Jackass star has spoken publicly about his struggles with substance abuse and addiction in the past, and committed to a 12-month treatment programme back in 2021.Margera confirmed the news to TMZ, revealing that he is set to continue attending outpatient treatment sessions for months. A member of the Jackass crew since the early days of the programme, Margera was absent from the recent sequel, Jackass Forever.Margera claimed he was fired from…

Mac Miller Drug Supplier Gets 17 Years in Prison Over Fatal Pills – The Hollywood Reporter

A California man charged with supplying fentanyl-laced pills before Mac Miller’s fatal 2018 overdose was sentenced Monday to more than 17 years in prison. At a hearing in Los Angeles federal court, U.S. District Judge Otis D. Wright sentenced Stephen Andrew Walter to 210 months in prison over his role in Miller’s death. As part of a November plea deal, Walter admitted to supplying a drug dealer with the counterfeit oxycodone pills that ultimately made their way to Miller. Walter pleaded guilty to a single count…