methylation

Radiomics in OncologyPhoto by National Cancer Institute on UnsplashIntroductionToday, we’re going to explore a study done for glioblastoma patients that was published in the journal Nature, Scientific Reports: Improving MGMT methylation status prediction of glioblastoma through optimizing radiomics features using genetic algorithm-based machine learning approach. The goal of this study was to try to predict O6-Methylguanine-DNA-methyltransferae (MGMT) methylation status. The reason why it is important to be able to…

A study by Northwestern Medicine links recent and long-term marijuana use to changes in the human epigenome. The research identified significant epigenetic changes through observing DNA methylation markers. While the study does not establish causal relationships, it sets the stage for further research into marijuana’s epigenetic impact and its potential health effects.Recent and long-term marijuana use is linked to changes in the human epigenome, a new Northwestern Medicine study published in the journal Molecular…

Researchers from UNSW Sydney have fully delineated the process of methylation, a key cellular procedure involving the addition of a ‘tagging’ methyl group to proteins, DNA, and other molecules, influencing cellular behavior and protein synthesis. This landmark study, drawing on a comprehensive review of the literature and utilizing yeast as a model organism, proposes a nearly complete picture of the methylation system, paving the way for new inquiries into the overall system function and potential applications in areas…

Researchers have identified markers that may indicate early-life susceptibility to schizophrenia, potentially allowing for early detection and intervention. The international research team used blood samples drawn shortly after birth and analyzed 24 million methylation marks, validating their findings with transcriptional data from 595 postmortem brain samples. They concluded that certain differences in methylation in newborns indicate an increased risk of developing schizophrenia later in life.The ability to predict the…

Scientists from Mount Sinai have provided fresh insights into the involvement of DNA methylation in Alzheimer’s disease (AD). According to their study, DNA methylation has a significant influence on the co-expression networks of genes and proteins related to AD. Consequently, this could potentially uncover novel neuropathological processes and molecular mechanisms, ultimately resulting in the development of innovative therapeutic interventions for Alzheimer’s disease.Findings from novel analytic approach could contribute…

…