NearAtomic

After the impact of AI on biology, this could represent another milestone, this time rooted in pure physicsScreenshot of a video made by Jan Stevens, shown with his permission as granted in this Twitter thread. Each particle shown in this model of the minimalist JCVI-syn3A cell is a whole macromolecule, modeled at coarse-grained level which means that small sets of atoms were groups into beads (see text for details).Advances in technology and the rise of data science have led to an exciting new era in biological research,…

Scientists have revealed, for the first time and in near-atomic detail, the structure of the key part of the inner ear responsible for hearing.Discovery made possible by state-of-the-art imaging and more than 60 million worms.For the first time and in near-atomic detail, scientists at Oregon Health & Science University (OHSU) have revealed the structure of the key part of the inner ear responsible for hearing.“This is the last sensory system in which that fundamental molecular machinery has remained unknown,” said…

This illustration is inspired by the Paleolithic rock painting in the Lascaux cave, signifying the acronym of our method, ROCK. Figuratively, the patterns of the rock art in the background (brown) are the 2D projections of the engineered dimeric construct of the Tetrahymena group I intron, while the main object in the front (blue) is the reconstructed 3D cryo-EM map of the dimer, with one monomer in focus and refined to the high resolution that allowed the collaborators to build an atomic model of the RNA. Credit: Wyss…