mRNA mod responsible for off-target effects identified & fixed
Researchers have discovered that a chemical modification to the synthetic messenger RNA used in therapeutics can cause the cell’s machinery to misread its instructions and result in unintended immune responses. Importantly, they’ve also discovered a solution to the problem.Messenger RNA, mRNA, tells cells in the body how to make a specific protein. It’s also an effective way of combatting disease, exemplified by its use in vaccines for SARS-CoV-2 and personalized cancer vaccines. mRNA therapeutics came about when…