Parkinsons

A novel therapy designed to clear toxic clumps of a protein thought to be responsible for Parkinson's disease has shown promise in early clinical trials.Produced by the US biotechnology company Vaxxinity, the immunotherapy candidate codenamed UB-312 is the first treatment shown to be capable of reducing concentrations of alpha-synuclein (α-syn) in cerebrospinal fluid, marking a significant step forward in slowing – or even halting – the disorder's progress.Though the results of the trial are yet to be published and peer…

Scientists have discovered that the brain’s activity during sleep, particularly the generation of rhythmic brain waves, is crucial for flushing out waste. This process could offer new strategies for preventing neurodegenerative diseases and improving sleep efficiency, potentially reducing the necessity for long sleep durations.Findings could pave the way for innovative strategies to tackle Alzheimer’s and various other neurological disorders.There lies a paradox in sleep. Its apparent tranquility juxtaposes with the…

Recent research indicates that pesticides and herbicides used in farming could be contributing to higher rates of Parkinson’s disease in certain U.S. regions, emphasizing the need for more in-depth studies and potential reduction in pesticide usage to mitigate disease risk.A preliminary study recently presented at the American Academy of Neurology’s 76th Annual Meeting has linked pesticides and herbicides used in farming to Parkinson’s disease in the Rocky Mountain and Great Plains region of the country“We used geographic…

A groundbreaking study reveals dopamine’s crucial role in controlling movement sequence lengths, shedding light on potential treatments for Parkinson’s Disease symptoms beyond traditional reward and pleasure associations. Credit: SciTechDaily.comDopamine’s influence extends to regulating movement lengths, offering new therapeutic targets for Parkinson’s Disease.Dopamine, a chemical messenger in the brain, is mostly known for its role in how we experience pleasure and reward. However, new research from the Champalimaud…

A new study highlights the role of misfolded tau proteins in the genesis and trajectory of Parkinson’s disease. Credit: Jason Drees/ASUNew research identifies tau protein as a key player in the early stages of Parkinson’s disease, challenging traditional views and suggesting new directions for treatment.Parkinson’s disease, the second most common type of progressive dementia after Alzheimer’s disease, affects nearly 1 million people in the U.S. and an estimated 10 million individuals worldwide. Each year, close to 90,000…

A new study reveals a potential treatment strategy for neurodegenerative diseases by targeting astrocytes with drugs that inhibit HDAC3, protecting nerve cells and offering hope for advancements in therapies for conditions such as Alzheimer’s and Parkinson’s. Credit: SciTechDaily.com Researchers identify new therapeutic approach targeting astrocytes, the brain’s most abundant cells.A team led by scientists at the Case Western Reserve University School of Medicine has identified a new therapeutic approach for combating…

Breadcrumb Trail LinksMusic'The important thing is to persevere and remind myself of the wonderful career I’ve had in music' Get the latest from Mark Daniell straight to your inbox Sign Up Published Feb 22, 2024  •  3 minute read Mick Jones seen onstage at Ottawa's Bluesfest in 2014. Photo by Wayne Cuddington /Postmedia NetworkArticle contentForeigner founder and guitarist Mick Jones has revealed that he’s been diagnosed with Parkinson’s disease.Jones, 79, made the announcement as he explained why he hasn’t played…

Foreigner co-founder and guitarist Mick Jones revealed that he is battling Parkinson’s disease, shedding some light on the unspecified health issues that have often kept him off the stage for the past several years. In a statement (shared via Billboard), Jones said, “Fans will have become very aware that for some time now, I have not been performing onstage with the band. Several years ago, I was diagnosed with Parkinson’s disease. I want everyone to know that I am doing alright.”  Jones, the sole remaining…

Scientists are investigating whether an oral drug sprinkled with gold nanoparticles could one day treat neurodegenerative diseases like Parkinson's and multiple sclerosis.The experimental medicine, called CNM-Au8, has now shown success in boosting the brain's metabolism in phase II clinical trials.Research on the safety and efficacy of the daily drug is still ongoing, but the initial results have researchers hopeful. The medicine contains suspended nanoparticles of gold that can apparently pass the blood-brain barrier…

Developing treatments for Parkinson’s disease is difficult due to its complexity, involving genetic, environmental factors, and a wide range of symptoms. A recent study proposes a new classification system called “SynNeurGe,” focusing on biological markers like alpha-synuclein, neurodegeneration, and genetics to enable earlier diagnosis and tailored treatments, a significant shift from current symptom-based diagnosis methods.Scientists propose a new model for classifying Parkinson’s.The complexity of Parkinson’s disease…