Pharmacology

By St. Jude Children's Research Hospital February 17, 2024By looking at each individual component of the β2 adrenergic receptor and seeing how they contribute to the overall function of the protein, researchers from St. Jude along with international collaborators are able to view the network that allows ligand binding to be translated across the membrane to within the cell. Artwork by Zhaowen Luo. Credit: St. Jude Children’s Research HospitalScientists at St. Jude Children’s Research Hospital, collaborating…

Researchers have created an AI model to predict the best methods for synthesizing drug molecules, significantly improving efficiency and sustainability in pharmaceutical development.Researchers have created an artificial intelligence system capable of predicting where a drug molecule can be chemically altered.A collaborative team from LMU, ETH Zurich, and Roche Pharma Research and Early Development (pRED) in Basel has employed artificial intelligence (AI) to devise a novel technique for predicting the optimal method for…

Cambridge researchers, in collaboration with Pfizer, have created an AI-driven ‘reactome’ platform to predict chemical reactions, expediting drug design. This innovative approach utilizes machine learning and automated experiments, significantly improving the accuracy and speed of pharmaceutical development. Credit: SciTechDaily.comThe ‘reactome’, an AI-powered platform developed by Cambridge and Pfizer, revolutionizes drug design by accurately predicting chemical reactions, streamlining the pharmaceutical development…

A study in Addiction shows that cytisine, a cost-effective smoking cessation aid from Eastern Europe, significantly increases quit rates compared to a placebo and might be more effective than nicotine replacement therapy. Safe and used since the 1960s, its availability is limited to certain countries, impacting its potential global health benefits, especially in low- and middle-income nations.Cytisine, a generic smoking cessation aid, has been shown to double the success rate of quitting smoking compared to a placebo.…

By St. Jude Children's Research Hospital December 20, 2023Researchers at St. Jude Children’s Research Hospital have elucidated the structures of VMAT2, a transporter crucial in neuronal communication, revealing how it interacts with drugs used to treat disorders like Tourette syndrome. This groundbreaking work offers insights into neurotransmitter transport, advancing the field of neuropharmacology.Neurons communicate through chemical signals known as neurotransmitters. Researchers at St. Jude Children’s Research…