“Hard To Lose” Mutations in Tumors May Predict Response to Immunotherapy
The figure shows the interactions between immune cells (white) and tumor cells harboring persistent mutations (red) in the context of immunotherapy (white) as a chess match captured in 5 snapshots. The piece placement is pulled from a Kasparov vs Deep Blue game. Credit: Christina Kostandi and Valsamo AnagnostouCancer specialists have attempted to utilize the number of mutations in a tumor, known as the tumor mutation burden (TMB), to forecast a patient’s response to immunotherapy, with varying degrees of success.…