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A new gene therapy that inhibits targeted nerve cell signaling effectively reduced neuropathic pain in mice with spinal cord or peripheral nerve injuries with no detectable side effects.In mouse studies, pain-blocking neurotransmitters produced long-lasting benefits without detectable side effects.An international team of researchers led by scientists at the University of California San Diego School of Medicine reported that a gene therapy that inhibits targeted nerve cell signaling effectively reduced neuropathic pain in…

By University of Texas M. D. Anderson Cancer Center May 29, 2022Study shows combined IL-6 and immune checkpoint blockade reduces toxicity while preserving anti-tumor immune responseThe University of Texas MD Anderson Cancer Center researchers have developed a unique technique for reducing immune-related side events associated with immunotherapy treatment by targeting the cytokine interleukin-6 (IL-6). The study, published in Cancer Cell on May 9th, 2022, establishes a proof of concept for combining immune checkpoint…

For the past six weeks, Johnny Depp's $50 million defamation trial has remained a viral case, as over 100 hours of testimonies have been delivered in the Virginia court and broadcast on CourtTV. Following riches of information from Depp and his lawyers on his side of the story and Amber Heard’s defense, a seven-person jury is tasked with coming to a unanimous decision regarding whether Heard defamed the Pirates star. So what happens next? The jury will continue to deliberate on the case after the holiday weekend, this…

Credit: CC0 Public Domain Researchers at Iowa State University found significantly different state tax rates affect where new businesses set up shop near state lines. Their study published in the journal Small Business Economics shows the fourth greatest distortion in the U.S. is between Iowa and its northwest neighbor. …

In early 1983, a Düsseldorf band called Propaganda got a message: Trevor Horn wanted them to come to London. It was an enticing and deeply improbable turn of events. Horn was the UK’s hottest pop producer, a man who had unexpectedly turned the hopelessly drippy duo Dollar into a critical cause célèbre and piloted ABC’s debut The Lexicon of Love to platinum-selling transatlantic success, also making it the fourth biggest-selling album of 1982 in the UK.Propaganda, however, were no one’s idea of a pop band. They were…

The initial plan was to interview Brendan Gleeson in central Dublin. A chat over lunch in a local pub or restaurant, then a few photos of him in his element. His agents politely point out this is not ideal. Why not? “Because he’s Brendan Gleeson!” He can no more walk around the centre of Dublin incognito and uninterrupted than could Bono, or the pope.So our rendezvous is relocated to a seafood restaurant at the end of a fishing pier in a village outside Dublin. But even here, within seconds of Gleeson posing for…

The legal battle between Johnny Depp and Amber Heard in these weeks has been a wild affair, whether we’re talking solely about the events that have been viewable on TV or also taking into account the online commentary. We’ve also seen how quickly things can change with this defamation trial. For instance, it was reported that Depp was expected to take the stand as a rebuttal witness on Wednesday or Thursday, but now it’s looking like that might not happen anymore, with a source close to Heard’s side using a bicycle and…

Schwinn’s electric bicycle line has significantly expanded over the last couple years. When I first started riding electric Schwinns, I was largely limited to cruiser e-bikes. But with several new commuter-specific e-bikes like the Schwinn Coston CE that I recently tested, this household bicycle name is making a big move on the wider e-bike market. The Schwinn Coston CE falls in the middle of its e-bike model line, offering a slight upgrade over the Schwinn Marshall but without some of the features found on the…

Breadcrumb Trail Links Toronto FC Soccer MLS Publishing date: May 19, 2022  •  10 minutes ago  •  4 minute read  •  Join the conversation Apr 30, 2022; Toronto, Ontario, CAN; Toronto FC midfielder Jonathan Osorio (21) controls the ball against FC Cincinnati midfielder Luciano Acosta (10) during the first half at BMO Field. Photo by John E. Sokolowski /USA TODAY Sports Reviews and recommendations are unbiased and products are independently selected. Postmedia may earn an affiliate…

If you have ever wondered from where the death-row lawyer Clive Stafford Smith gets his intransigent, crusading spirit, this vivid, inquiring memoir provides much of the evidence. It is set up as a book not about its author but about the lives of two very different men who helped to define him. The first is Stafford Smith’s father, Dick, a wildly volatile man with bipolar disorder, who squandered the family fortune and blamed everyone but himself. The second is Larry Lonchar, an inmate in Georgia State Prison facing a…