Vaccine

A new intranasal vaccine candidate developed shows improved and longer-lasting immunity against COVID-19, potentially reducing the need for booster shots by enhancing mucosal and systemic immune responses.Duke-NUS-led research reveals an intranasal vaccine candidate that offers superior, long-lasting COVID-19 immunity, potentially minimizing booster requirements.Novel findings from a preclinical head-to-head comparison show that administering a COVID-19 vaccine as a nasal spray, rather than subcutaneous injection,…

A new study led by UAlbany's Massry School of Business explores how opposing viewpoints may have impacted vaccine hesitancy during the COVID-19 pandemic. Credit: U.S. Air Force Reserve Staff Sgt. Christopher S. Muncy As the COVID-19 pandemic raged throughout the country in 2020, politics, memes and public messaging converged to dramatically influence individuals' decisions regarding the in-development COVID vaccines, according…

A novel method for producing the key vaccine ingredient QS-21 in tobacco plants has been developed, offering a sustainable alternative to traditional extraction from the soapbark tree and enhancing vaccine manufacturing. Credit: SciTechDaily.comSoap bark discovery offers a sustainability booster for the global vaccine market, opening unprecedented opportunities for bioengineering vaccine adjuvants.A valuable molecule sourced from the soapbark tree and used as a key ingredient in vaccines, has been replicated in an…

Recent research indicates that COVID-19 vaccines offer moderate protection against long COVID in children, with greater effectiveness observed in adolescents.Vaccination associated with moderate protection in large, diverse cohort.Vaccination against SARS-CoV-2, the virus that causes COVID-19, reduces the risk of serious acute illness in children and adolescents. However, its role in protecting against persistent health problems in the months after COVID-19, or “long COVID,” was less clear.Now, researchers from 17 health…

A UCLA-led study finds that full-term infants born to mothers infected with COVID-19 during pregnancy are at a higher risk of respiratory distress, a condition significantly mitigated by maternal vaccination before infection. Credit: SciTechDaily.comInfants born to COVID-19 infected mothers face triple the risk of respiratory distress, according to UCLA research. Vaccinating mothers prior to infection significantly reduced the risk for full-term infants developing a breathing disorder that most often strikes premature…

Malaria expert Brian Greenwood had once resigned himself to the possibility that a successful vaccine for the disease might not become available in his lifetime. Now, at 86 years old, the moment he’s spent four decades working toward has arrived.“It’s been a long journey with many ups and downs,” says Greenwood, still an active researcher at the Royal Society of Tropical Medicine and Hygiene, leading vaccine trials across Africa. “The first attempts to develop a malaria vaccine through studies in birds were done over 100…

A new investigation exposes critical flaws in the U.S. Vaccine Adverse Event Reporting System (VAERS), highlighting its inability to effectively process and respond to the high volume of reports post-COVID-19 vaccine rollout. VAERS faces staffing challenges, communication issues, and transparency concerns, as updates to reports are not made public, leading to widespread frustration and questioning of its efficacy in vaccine safety monitoring.An investigation has raised concerns about the system not operating as intended…

A groundbreaking study by UC San Diego researchers reveals why Staphylococcus aureus (SA) vaccines fail in clinical trials, highlighting how SA tricks the immune system into producing ineffective antibodies and suggesting a new direction in targeting less dominant antigens for future vaccine development.Research conducted at UC San Diego provides insight into the clinical failure of numerous potential vaccines for widespread human infection and proposes a solution to overcome this issue.Staphylococcus aureus (SA) is a…

Transmission electron micrograph of HIV-1 virus particles (red) budding and replicating from a segment of a chronically infected H9 cell (blue). Particles are in various stages of maturity; arc/semi-circles are immature particles that have started to form but are still part of the cell. Immature particles slowly change morphology into mature forms and exhibit the classic “conical or spherical-shaped core.” Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAIDResearchers…

Researchers have developed a guide for detecting rare B cells, crucial in understanding food allergies and immune responses. Utilizing a technique involving antigen tetramers, this work facilitates the study of these cells’ diverse roles, from combating diseases to causing allergies. The research also extends to assessing vaccine efficacy, potentially aiding global scientific advancement. Credit: SciTechDaily.comResearchers have developed a guide for detecting rare B cells, crucial in understanding food allergies and…