antiobesity

To go through life in a fat body means you are less likely to be hired for a job and will be paid less than non-fat people. The effects of weight discrimination—which can include poorer medical treatment, loneliness, psychological distress, and increased stress—may actually be cutting short the lives of fat people.Deciding whether to take the drugs becomes  a “devil’s choice,” says Osborn. “Assert that I have the right to be as I am right now—or exchange that right for significantly more rights and privileges in the…

An experimental anti-obesity drug developed several years ago by researchers at the Salk Institute has been found to prevent intestinal inflammation in mice. The drug has yet to be tested in humans but the findings point to a novel way to prevent flare-ups in patients suffering from inflammatory bowel disease (IBD).Farnesoid X receptor (FXR) is a protein expressed in the liver and intestine. When we start eating a meal, and bile acids begin to build up, FXR triggers a variety of metabolic processes to aid digestion and…

Porous particles of silica made from purified sand could one day play a role in attempts to lose weight.Past clinical trials have already produced promising results, but the actual weight-lowering mechanism behind the potential treatment has been poorly understood.To sift out the key variables, researchers have now tested a range of silica sizes and shapes in a simulation of the human gut after a heavy meal.The results support the idea that porous silica can "impede the digestive processes" that are usually triggered by…

The people who seek out endocrinologist Domenica Rubino have tried again and again to lose weight. Diets of all kinds. Exercise regimens. Health-tracking apps. Some have turned to gastric bypass surgery, lost scores of pounds but then regained them. Many patients have medical problems related to severe obesity, including diabetes, fatty liver disease, hypertension, polycystic ovary syndrome, sleep apnea and painful arthritic joints. Rubino, director of the Washington Center for Weight Management and Research in Arlington,…

Preliminary data from a large Phase 3 clinical trial is offering promising signs for a new anti-obesity drug. Called tirzepatide, the drug helped overweight and obese participants lose up to 22.5 percent of their total body weight over the 72-week trial.Last year the US Food and Drug Administration (FDA) approved a drug called Wegovy (or semaglutide) as a weight management tool for obese or overweight people. Wegovy was the first of a new class of anti-obesity treatments to be approved by the FDA.These drugs are designed…