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Gene Therapy Reverses Effects of Autism-Linked Mutation in Human Brain Organoids

Microscopy images reveal significant differences in size and structure between brain organoids derived from a patient with Pitt-Hopkins Syndrome (right) and from a control (left). Credit: UC San Diego Health SciencesUniversity of California San Diego (UCSD) study uses lab-grown human brain tissue to identify neural abnormalities in Pitt-Hopkins Syndrome and test gene therapy tools.In a study published on May 02, 2022, in the journal Nature Communications, scientists at the University of California San Diego School of…

“Reset button” for cells in the brain hints at new treatments for concussion

The way the brain responds to traumatic injuries is a matter of intense interest to medical scientists investigating concussion and its significant health impacts. Through experiments on mice in which a key set of immune cells were essentially reset after the injury, researchers have shown how a heightened sense of alert may drive some of the long-term consequences to cognitive function, and opened up new possibilities around post-concussion therapies for human sufferers.Carried out by scientists at Ohio State University,…