Cell biology

A new study reveals how the coronavirus SARS-CoV-2 interacts with Fragile X-related proteins, impacting its spread and suggesting increased vulnerability for individuals with Fragile X Syndrome. Credit: SciTechDaily.comResearchers have found an unexpected connection between coronavirus and Fragile X Syndrome, which is the most common hereditary cause of intellectual disability.How does coronavirus spread through the body? A new study can help us answer that question. Professor Jakob Nilsson from the Novo Nordisk…

Research suggests that endogenous retroviruses within the human genome could influence the development of neurodegenerative diseases by contributing to the spread of abnormal protein aggregates in the brain. Credit: SciTechDaily.comResearchers See Ancient Genes As Potential Targets for Dementia TreatmentGenetic remnants of viruses that are naturally present in the human genome could affect the development of neurodegenerative diseases. Researchers at DZNE come to this conclusion on the basis of studies on cell cultures.…

The study reveals that the RNA modification N4-acetylcytidine (ac4C) plays a crucial role in the formation of stress granules and the cellular response to stress, offering new insights into the molecular mechanisms involved and identifying potential targets for disease treatment.Stress granules play a crucial role in the stress response, arising from the aggregation of non-translating mRNAs and proteins. Although significant knowledge exists about stress granules, the mechanisms behind their mRNA localization remain…

Discoveries about the end-replication problem indicate both telomerase and the CST–Polα-primase complex are essential for chromosome protection, suggesting a revision in the science of telomeres and potential impacts on genetic disorders. Credit: SciTechDaily.comRecent research challenges the long-standing understanding of the end-replication problem in DNA, revealing two distinct issues rather than one.Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how…

Senescence, or the state where cells stop growing and release harmful molecules, leads to various age-related diseases, with Mayo Clinic research uncovering the biology behind aging cells and identifying specific biomarkers that can predict health outcomes. A study on “rogue” mitochondria in senescent cells revealed a new phenomenon that could potentially improve health in older adults by reducing tissue inflammation and enhancing vitality.As individuals age, their cells may undergo senescence, a condition in which cell…

By Okinawa Institute of Science and Technology (OIST) Graduate University February 25, 2024A groundbreaking study has discovered that cell membrane damage can lead to cellular senescence, a state associated with aging and disease. This adds a third possible outcome to the previously understood consequences of cell damage—recovery or death. The research highlights the impact of moderate membrane damage on cell fate and opens new paths for promoting healthy aging by understanding and manipulating the underlying mechanisms…

New research in mice may pinpoint how chronic stress can fuel the spread of cancer. The study found evidence that stress can induce changes to certain immune cells that inadvertently make it easier for cancer cells to metastasize and invade other parts of the body. The findings emphasize the need to manage stress following a cancer diagnosis, the scientists say, and could even help efforts to find new treatments.Dave Bautista Opens Up About His Relationship With Denis VilleneuveThe research was led by scientists at Cold…

Illustration of a diPUFA phospholipid, a type of lipid with two polyunsaturated fatty acyl tails, breaking through a cell’s outer lipid layer as the cell dies. New research has shown that diPUFA phospholipids are a key driver of a form of cell death known as ferroptosis. Credit: Nicoletta Barolini/Columbia UniversityScientists have discovered that a rare lipid type plays a pivotal role in ferroptosis, a form of cell death. This finding sheds light on the mechanisms of cell death in ferroptosis and opens up possibilities…

Researchers at Kyoto University have discovered that talin proteins play a crucial role in cell migration and mechanosensing by dynamically stretching to connect cellular matrices, challenging existing beliefs about cellular force transmission. Credit: SciTechDaily.comTalin’s springy role in force transmission and dynamic cellular bridging.Cell biology has possibly never jumped to the next level in the same way.In multicellular organisms, cell migration and mechanosensing are essential for cellular development and…

A groundbreaking study reveals how neutrophils form their unique nuclear structures, solving a mystery from the 1880s. This discovery could revolutionize immune therapy by enabling the engineering of immune cells with new nuclear shapes to enhance their disease-fighting capabilities.Scientists may be able to direct immune cells toward diseased areas. Nearly 150 years ago, scientists discovered that specialized blood cells serve a vital role in immune system protection against infection and illness.Certain groups of these…