Differentiation

Researchers from Johns Hopkins University have discovered how histone H3, a protein in roundworm chromosomes, enables offspring to produce specialized cells generations later, challenging the idea that hereditary information for cell differentiation is mostly contained in DNA. The study, published in Science Advances, found that histone H3 levels in roundworm embryos controlled the production of specialized cells and pluripotent cells, which can differentiate into various body tissues. The researchers also found that…

Human stem cells can differentiate into any human cell. But the process of dedifferentiation, essentially differentiation in reverse, is implicated in several diseases. Now researchers have uncovered a mechanism that is key to the process of stem cell dedifferentiation, opening the door to the development of new disease treatments.Human pluripotent stem cells (hPSCs) self-renew, differentiating and developing into specialized, more advanced cell types in a one-way process. Despite previous studies examining the signaling…

Bathymetric map of the northern East Pacific Rise (EPR) and the vicinity and the sampling locations. Credit: IOCAS Zinc (Zn) isotope systematics is a useful tool to study planetary evolution and trace carbon cycling in the Earth's mantle. However, zinc isotope data for mid-ocean ridge basalts (MORB), the most widespread magmatic rocks on Earth, are scarce. The possible effects of MORB differentiation and mantle compositional…

According to TrendForce analysts, the chances of the iPhone 15 Pro and iPhone 15 Pro Max getting increased RAM are high. The Apple iPhone 15 Pro and iPhone 15 Pro Max are tipped to come with 8GB RAM next year, higher than the iPhone 14 series, and presumably next year’s vanilla models – the iPhone 15 and iPhone 15 Plus (if there is one). The iPhone 14 Pro and iPhone 14 Pro Max were also said to come with higher RAM earlier, but the new iPhone models launched with 6GB RAM. According to the report, Apple wants the enhanced…

Portable hard drives aren't really exciting anymore – there's very little to differentiate one brand from another and you'll often just buy whichever is priced lower. Still, everyone needs a hard drive for backups – even if you think you don't, you do. Some companies have tried innovating with design, but there's isn't much that anyone can do with a plastic rectangle. We've also seen bundled backup and security software as a value-add, which might help swing buyers' decisions. Seagate has tried both these avenues with its…

Perform rapid loss-function prototypes to take full advantage of XGBoost’s flexibilityPhoto by Matt Artz on UnsplashMotivationRunning XGBoost with custom loss functions can greatly increase classification/regression performance in certain applications. Being able to quickly test many different loss functions is key in time-critical research environments. Thus, manual differentiation is not always feasible (and sometimes even prone to human errors, or numerical instability).Automatic differentiation allows us to…