Eliminating

Research led by Dr. Manuel Serrano at IRB Barcelona has unveiled how senescent cancer cells, post-chemotherapy, employ the PD-L2 protein to evade immune detection and foster a suppressive environment, hindering lymphocyte function. Deactivating PD-L2 in these cells allows the immune system to efficiently eliminate them, enhancing the effectiveness of chemotherapy. This finding, demonstrated in cell and animal models of various cancers, suggests the potential of PD-L2 inhibitors in improving cancer treatments. Credit:…

Updated Jan. 16, 2024 5:13 pm ETA federal judge on Tuesday blocked JetBlue Airways’ $3.8 billion deal to buy Spirit Airlines, rejecting a merger that he said would hamper competition and lead to higher fares.The ruling thwarts what would have been the biggest U.S. airline merger in over a decade. It marks a victory for the U.S. Department of Justice, which sued last year to prevent JetBlue and Spirit from going ahead with their tie-up.Copyright ©2024Dow Jones & Company, Inc. All Rights Reserved.…

If you've ever found yourself unable to place a call, access data, or even send a text message with your iPhone and wished that true global coverage was a thing, you're going to love the work that Starlink is doing. CEO Elon Musk shared details of six new satellites that are now in orbit and are designed to make cellular dead zones a thing of the past.As great as cellular coverage has gotten in recent years there are still plenty of places where you simply can't get a signal. That's something Apple is all to aware of and…

In the race to reach carbon neutrality, many businesses are looking for various ways to cut emissions, whether through limiting high-carbon transit, becoming more energy efficient at home, or reducing our consumption of meat. But there are some things that individual consumers can do that don’t require massive lifestyle changes, making them more likely options for regular folks who want to help the planet but don’t want to give up their holiday travel schedule. One such method is reducing food…

Tinder is for finding love — or at least a temporary connection — but the app’s backers aren’t interested in helping people expand their connections beyond the narrow confines of its own jurisdiction. The company says that it has identified an issue with users turning their profiles into spaces for “making money,” and will scrub social handles from public profiles, as well as tweaking its community guidelines to prohibit the sharing of usernames or references to other outbound links. In a statement rich in euphemism, the…

Map of countries with published NAPs on Minamata Convention's official website (red), national government websites (blue), and NGO (Non-Governmental Organization) websites (green). Credit: Environmental Science & Policy (2023). DOI: 10.1016/j.envsci.2022.12.002 A global treaty called the Minamata Convention requires gold-mining countries to regularly report the amount of toxic mercury that miners are using to find and…

Photo by Jason Goodman on UnsplashLean Six Sigma practices are industry-standard in manufacturing, but the same principles are readily transferrable and transformational when applied to your digital teams in software development and productionLean Six Sigma and related total quality management systems have been around for decades, and have had multiple predecessors stemming back from W. Edwards Deming and succeeding to specific quality systems in individual sectors such as Agile Project Management in tech.While the clear…

Pedestrians walk past a Gap Inc. store in Shanghai, China.Qilai Shen | Bloomberg | Getty ImagesGap Inc. is cutting about 500 corporate jobs as the clothing retailer struggles with declining sales.The job cuts, which include open positions, will be primarily at Gap's offices in San Francisco, New York and Asia and hit various departments, a representative for the retailer confirmed Tuesday. The moves were first reported by The Wall Street Journal.The San Francisco-based company has experienced a slew of setbacks, including…

Artificial intelligence (AI) continues to demonstrate its worth, innovating operations and optimizing workloads for organizations across all industries. As more industries look to harness the power of AI, we must be extra sensitive to the data we are using to train this technology. If we aren’t, we risk backsliding against all the progress society has made in recent times in relation to intrinsic bias against Black, Indigenous, and People of Color (BIPOC).  The rise of synthetic dataBusinesses are using AI to venture into…

James Webb Space Telescope has completed the complex process of deploying its kite-shaped sunshield. The sunshield, about the size of a tennis court, has five layers. The first three were deployed initially and the last two were done late last night. Deploying all five layers was crucial for the $10-billion (roughly Rs. 74,525 crore) space observatory. The sunshield will keep the telescope cool enough to enable it to begin its quest to capture images of faraway stars and planets.NASA said the tensioning of the sunshield…