“Sugar Hypothesis” of Diabetic Cataract Development Gets an Eye-Opening Reality Check
New findings challenge the “sugar hypothesis” in diabetic cataracts, revealing that immune cells cause cellular changes in the eye lens before high blood sugar levels occur. This suggests diabetic complications may begin during the pre-diabetic state and calls for a reevaluation of current theories.In preclinical models, investigators uncovered a novel mechanism underlying the development of diabetic cataracts that undermines current hypothesis.Researchers at Brigham and Women’s Hospital have discovered a novel mechanism…