MRNA

Recent studies have highlighted a challenge in mRNA therapeutics: the tendency of cellular machinery to misinterpret modified mRNA sequences, causing unintended immune responses. Researchers are now refining mRNA vaccine designs to prevent these ‘off-target’ effects, ensuring the future safety and effectiveness of these groundbreaking treatments. Credit: SciTechDaily.com Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body.…

Caltech scientists have developed a new type of vaccine that works like a hybrid of mRNA and protein nanoparticles. In tests in mice, the prototype produced five times more antibodies than existing COVID-19 vaccines, and could be put to work against a range of diseases.The general principle of a vaccine is to train a person’s immune system to recognize a pathogen, such as influenza or SARS-CoV-2 viruses, so that they can more effectively fight them off during future infections. This is usually done by introducing proteins…

China remains attractive to global pharmaceutical companies even as many multinationals shift their focus elsewhere. China remains attractive to global pharmaceutical companies even as many multinationals shift their focus elsewhere. FOLLOW US ON GOOGLE NEWS Read original article here Denial of responsibility! Techno Blender is an automatic aggregator of the all world’s media. In each content, the hyperlink to the primary source is specified. All trademarks belong to their rightful owners, all materials to…

Nikos Pekiaridis | Nurphoto | Getty ImagesModerna on Wednesday said it struck a deal with Chinese officials to research, develop and manufacture messenger RNA medicines in the country, despite rising tensions between the U.S. and China. The Massachusetts-based biotech company signed a memorandum of understanding and a related land collaboration deal to develop drugs that will "be exclusively for the Chinese people" and "not be exported," a Moderna spokesperson told CNBC.  Chinese media outlet Yicai first reported on…

Scientists have developed and tested a new potential treatment for cancer that works in a similar way to the COVID-19 vaccines. The technique involves delivering mRNA molecules to cancer cells and tricking them into producing toxic proteins that kill the tumors.Inside all living cells are ribosomes, which are essentially tiny factories that produce proteins. Exactly which proteins they make depends on the 'blueprints' they receive, and these come from messenger RNA (mRNA) molecules.Over the past few decades, scientists…

Researchers have designed a new nanoparticle that was shown to more effectively deliver a cancer-fighting mRNA vaccine to mice. The study’s results may lead to the development of better vaccines to treat cancer and infectious diseases like COVID-19.Cancer treatment has been revolutionalized by advances made, and continuing to be made, in the field of immunotherapy, the treatment of disease by activating or suppressing the body’s immune system. But each patient’s cancer tumor is unique, requiring treatments that target…

New Delhi: The Department of Biotechnology (DBT) on Tuesday announced that the Omicron-specific mRNA-based Booster vaccine developed using the indigenous platform technology by Gennova Biopharmaceuticals has got a nod from the office of the Drug Control General of India (DCGI) for Emergency Use Authorization (EUA).…

FERRY can travel in both directions along intracellular road networks. Credit: Schuhmacher et al. (2023) / MPI-CBGCollaborative efforts from teams at the MPI Institutes located in Dresden, Dortmund, Frankfurt am Main, and Göttingen have led to the first evidence of a protein complex that plays a crucial role in transporting messenger <span class="glossaryLink" aria-describedby="tt" data-cmtooltip="<div class=glossaryItemTitle>RNA</div><div class=glossaryItemBody>Ribonucleic…

The following essay is reprinted with permission from The Conversation, an online publication covering the latest research. While effective vaccines for COVID-19 should have heralded the benefits of mRNA vaccines, fear and misinformation about their supposed dangers circulated at the same time. These misconceptions about mRNA vaccines have recently spilled over into worries about whether their use in agricultural animals could expose people to components of the vaccine within animal products such as meat or milk. In…

Vaccines against Covid-19 were delivered with remarkable and unprecedented speed. The ones pioneered by Moderna in the US and BioNTech in Germany introduced the lay public to a new kind of shot: one that includes mRNA, the nucleic acid that normally carries genetic instructions from the cell nucleus to the part of the cell where proteins are made. How could this novel technology have come together so rapidly? In fact, the approach had long been in the works, although it was not initially intended to prevent viral…