Nasal

Researchers in Australia have developed a nasal spray that could lessen sleep apnea’s severity and decrease blood pressure, providing a new potential treatment for the widespread condition.Australian researchers have discovered that a bedtime nasal spray has the potential to reduce the severity of sleep apnea in people and lower their blood pressure.The new research published in The Journal of Heart and Circulatory Physiology offers hope to millions of people around the world affected by sleep apnoea, a common and…

A new intranasal vaccine candidate developed shows improved and longer-lasting immunity against COVID-19, potentially reducing the need for booster shots by enhancing mucosal and systemic immune responses.Duke-NUS-led research reveals an intranasal vaccine candidate that offers superior, long-lasting COVID-19 immunity, potentially minimizing booster requirements.Novel findings from a preclinical head-to-head comparison show that administering a COVID-19 vaccine as a nasal spray, rather than subcutaneous injection,…

Researchers have developed an intranasal COVID-19 vaccine that enhances the immune system’s response to the virus, providing longer-lasting, greater protection than vaccine injections, even against new and emerging variants. The novel vaccine candidate could mean fewer boosters in future.While the immediate threat of the COVID-19 pandemic has dissipated somewhat, with most returning to their pre-COVID lives, the continued rise of new virus variants means that vaccination is still necessary to protect the vulnerable in the…

A recent study found esketamine nasal spray to be more effective than quetiapine extended-release in treating treatment-resistant depression, offering new hope for effective management of this challenging condition. Severe depression and treatment-resistant depression (TRD) are prevalent conditions. About one-third of patients show no improvement with standard treatments like selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). TRD contributes to a higher incidence of…

Respiratory illness season is here, and with it typically comes snotty, stuffy noses. Earlier this fall a Food and Drug Administration panel concluded that oral phenylephrine—a common active ingredient in cold and allergy medicines—is useless at clearing up congestion. Now that many of these over-the-counter drugs officially don’t work, what are some other remedies and medications adults and children can turn to?“It is always a hot topic,” says Andrew Lane, a rhinologist and director of the Johns Hopkins Sinus Center.…

Scientists have demonstrated how nasal drops containing a particular molecule can help mice recover from the damaging biological consequences of a stroke – and the hope is that the treatment could eventually be transferred to humans.Crucially, the treatment isn't applied straight away but is initiated seven days after the stroke. That means those who are unable to be assisted immediately after a stroke could still be protected against the worst effects of the condition.The key molecule in the drops is the complement…

By Max Delbrück Center for Molecular Medicine in the Helmholtz Association April 10, 2023Nasal vaccines are a type of immunization that are administered through the nasal passages rather than through injections. The advantage of nasal vaccines is that they offer a less invasive alternative to traditional injections, and they have been shown to be effective in providing immunity. Additionally, because they do not require the use of needles, they may be a good option for people who are needle-phobic or for children who may…

A new study in Rheumatology Advances in Practice reveals that Granulomatosis With Polyangiitis (GPA), a rare nasal disease causing blood vessel inflammation, may be frequently misdiagnosed as a result of nasal damage from cocaine use. Cocaine can induce the production of antibodies that mimic idiopathic GPA, making diagnosis difficult. The researchers conducted a retrospective review of patients at vasculitis clinics, finding that 86% had positive urine toxicology results for cocaine use. They recommend testing for…

The US Food and Drug Administration has approved a fast-acting nasal spray from Pfizer designed to treat migraines, the US pharmaceutical giant said Friday.​Pfizer said it expected the drug, marketed under the name Zavzpret, to be available in pharmacies in July 2023.​"The FDA approval of Zavzpret marks a significant breakthrough for people with migraine who need freedom from pain and prefer alternative options to oral medications," Pfizer chief commercial officer Angela Hwang said in a statement.​A Phase 3 study of the…

The nasal spray alleviated symptoms during sleep in approximately 40% of cases, and the number of children considered by a surgeon as requiring tonsil and/or adenoid removal was halved. Credit: Nenad StojkovicAccording to a new study, a simple nasal spray significantly improved snoring and breathing difficulties in children as well as reducing the number of children who needed tonsil removal by half.According to research led by the Murdoch Children’s Research Institute and published in JAMA Pediatrics, a saline (salt…