prostate

In three of the 21 cases Joshi Alumkal and his team studied, the gene expression of the prostate tumors changed after receiving enzalutamide and no longer had the androgen receptor (shown in red) as an engine. Credit: Courtesy of Joshi AlumkalBiopsies from the same patients before and after treatment reveal how a specific drug reprograms prostate cancer tumors.For more than a decade, drugs like enzalutamide (also known by the brand name Xtandi) that inhibit male hormones from activating the androgen receptor have been…

The researchers believe that the findings could make it possible for those with this kind of prostate cancer to get targeted treatments.A new and very prevalent kind of prostate cancerA recent study by a group of researchers at Memorial Sloan Kettering Cancer Center (MSK) and Weill Cornell Medicine finds that a previously unidentified subtype of hormone-resistant prostate cancer makes up roughly 30% of all cases. The study was recently published in the journal Science.  The discovery could make it possible for patients…

Microscopic image of prostate cancer that has spread to a patient’s lymph node. Credit: Netherlands Cancer InstituteTherapy sensitivity in prostate cancer halted by protein regulating circadian rhythm.Hormone treatment is successful at controlling metastatic prostate cancer, but the tumor cells eventually develop resistance to it. An unexpected potential solution has now emerged in medicines that are not designed to fight cancer, but rather to target proteins that regulate a cell’s circadian rhythm.An international team…

Scientists at Weill Cornell Medicine have identified two new subtypes of prostate cancer. These new forms of the disease are resistant to usual treatments, but categorizing and studying them could lead to new therapies.Most prostate cancers are fairly slow-growing, with a range of treatment options available. In some cases hormone therapy is administered, which reduces the levels of male hormones like testosterone that the cancer cells depend on to grow. However, some tumors can develop resistance to this treatment,…

Obesity increases a man’s risk of dying from prostate cancer, according to a massive new study by researchers in the UK, however, the causal mechanisms underpinning the link are not yet clear.Prostate cancer is one of the most common forms of cancer to be detected in men. It is a slow-growing form of cancer, so patients can live many years after diagnosis. In fact, many patients diagnosed with prostate cancer ultimately die of other causes before the cancer develops enough to cause its own problems.Because of the…

A landmark study has identified five types of bacteria associated with aggressive prostate cancer. It is unclear at this stage whether the bacteria is directly causing the cancer but the researchers are confident they can develop new tests to identify aggressive prostate cancer by tracking the presence of these bacteria."We already know of some strong associations between infections and cancer,” explained Colin Cooper, lead researcher on the project. “For example, the presence of Helicobacter pylori bacteria in the…