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Microbes stomp daffodils in creating valuable anti-Alzheimer’s drug

Using an AI-based approach, researchers found a better way to create the drug galantamine, commonly prescribed to people suffering from Alzheimer's and other forms of dementia. The fermentation-based technique could boost the drug's availability.While bacteria are perhaps most famous for causing diseases like strep throat and pneumonia, the tiny microbes can also be programmed to serve as the workhorses in chemical processes. For example, we've seen the probiotic Lactobacillus reuteri genetically engineered to secrete a…

Aviate Audio Multiverse Player Edition is a $349 ‘pedal store in a stomp box’

Last year Aviate Audio launched the Developer Edition of its Multiverse pedal — basically a plug-in host in guitar pedal format. Now, just in time for NAMM 2024, the company has announced the Player Edition of the Multiverse. The pedal is, for all intents and purposes, unchanged. Same basic design, same processor under the hood (a 600MHz Cortex M7), it's just cheaper now at $349, and presumably won't have access to some of the developer focused tools.The pedal itself has a small 1.3-inch OLED screen to navigate the UI.…

Gabriels review – brooding gospel soul with a shimmy and a stomp | Music

Like the recently renovated 1960s modernist concert hall that provides the setting for tonight’s show, gospel soul trio Gabriels have classic roots galvanised by top-end contemporary production. Tonight is the opening date on a short – and strictly sold out – UK tour promoting Angels and Queens Part One, the excellent debut album likely to score highly on end-of-year lists this winter.Jacob Lusk’s power as a vocalist, and his hard-utilised charisma, is immense. Taking to the stage in long, black gown and hat redolent of…