inherited

Award-winning actress Catherine O`Hara thinks she`s inherited her sense of humour from her family. The actress told Reader`s Digest magazine, "It was just a given in our family. Both my parents, God bless them, are gone but they were both really, really funny." "Mum raised seven kids, then she went into real estate, and at dinner, she would impersonate the people that she met that day. And my dad worked on the Canadian Pacific Railway and was such a joke teller that he would get into trouble for laughing too much at…

Researchers have uncovered a significant link between inherited genetic variants and the development of a rare blood cancer, myeloproliferative neoplasms (MPN). This breakthrough could improve clinical predictions and inform future treatments. Credit: SciTechDaily.comA groundbreaking study reveals how inherited genetic variants contribute to the development of rare blood cancer, offering insights for disease prediction and treatment strategies.Large-scale genetic analysis has helped researchers uncover the interplay…

Researchers have presented the interim results of a clinical trial that used a single infusion of CRISPR gene-editing technology to permanently switch off low-density lipoprotein cholesterol production in people with a genetic condition that causes elevated levels of the ‘bad’ cholesterol and increases the risk of early heart attack.Low-density lipoprotein cholesterol (LDL-C), so-called ‘bad’ cholesterol, is known to be a primary driver of atherosclerosis, the build-up of plaque on the walls of blood vessels that places…

A multi-institution research team, including Cornell University, used a new suite of computational genetic tools to examine how Neanderthal genes still actively influence human traits in people of non-African ancestry, revealing that certain Neanderthal genes significantly impact modern human immune systems and other traits. Analyzing nearly 300,000 UK Biobank datasets, they found 4,303 Neanderthal genetic variants affecting 47 distinct genetic traits, with modern human genes overall winning out over generations.Recent…

Researchers have identified a gene that is associated with taller noses in humans and found it likely comes from Neanderthals, an extinct hominin group intimately related to our own species.The Painted Skeletons of ÇatalhöyükNeanderthals (Homo neanderthalensis) died off around 40,000 years ago, making them the most recent hominin species to go extinct. But, in a way, they are still around, since most humans today are walking around with Neanderthal DNA. Lots of interbreeding between Homo sapiens and Neanderthals may have…

This hybrid book, which is not quite a memoir and not quite a conceptually linked essay collection, begins with the death of a young Irish woman called Grace Farrell, whose body was discovered outside St Brigid’s Church in Manhattan’s East Village on 20 February 2011. Having arrived in New York from Ireland in 1993 with the dream of becoming an artist, Farrell was 35, homeless, and an alcoholic when she froze to death in an alcove of the church on Avenue B on the coldest night of the year.Carmel McMahon came to New York a…

Zinkevych | iStock | Getty ImagesIf you inherited a retirement account in 2020 or 2021, the IRS is waiving penalties for some heirs who needed to start taking required minimum distributions right away, according to a notice issued Friday.The new rule won't apply until 2023.Typically, there's a 50% penalty when you skip RMDs or don't take the full amount by the deadline, applying to the balance that should have been withdrawn.Thanks to the Secure Act of 2019, certain heirs, known as "non-eligible designated beneficiaries,"…

When a high school athlete dies from a heart attack or a young woman needs a heart transplant, it is often because they inherited a DNA mutation that causes heart muscle disease. Today, in the biggest research grant ever from the research charity, the British Heart Foundation announced an award of £30 million ($36 million) over 5 years to an international team to develop gene-editing treatments for these deadly diseases. Called CureHeart, the project bested three others…

Breadcrumb Trail Links PMN Politics PMN News Author of the article: Article content THE CONVERSATION This article was originally published on The Conversation, an independent and nonprofit source of news, analysis and commentary from academic experts. Disclosure information is available on the original site. —— Author: Neal Sondheimer, Associate Professor of Paediatrics and Molecular Genetics, University of Toronto With the rising spectre of the loss of women’s reproductive autonomy in the United…