progression

Researchers at the University of Colorado Anschutz Medical Campus have discovered that inhibiting the Mdm2 protein with a drug called nutlin prevents the synaptic destruction associated with Alzheimer’s disease, offering a promising new avenue for therapy. This approach, which diverges from traditional strategies focusing on amyloid plaque removal, could potentially halt the disease’s progression and is set to undergo further testing in animal models.Researchers at CU Anschutz have discovered a new potential method to…

This picture taken on October 23, 2023, shows Ozempic medication boxes, an injectable antidiabetic drug, in a pharmacy in Riedisheim in eastern France.Sebastien Bozon | Afp | Getty ImagesNovo Nordisk's blockbuster drug Ozempic cut the risk of kidney disease progression and related health complications in diabetic patients, according to initial late-stage trial results released Tuesday. Ozempic specifically lowered the risk of kidney disease progression and death from kidney or cardiovascular complications by 24% in…

Players have reported problems across Call of Duty: Modern Warfare 3 and Warzone with server issues affecting multiplayer, Zombies, and battle royale. Activision has commented on the issues--including that they may also impact Modern Warfare 2--but here's what you need to know before logging in to play.You can still try to hop into matches of Modern Warfare 3 and Warzone, but you'll want to beware that in addition to difficulty finding matches, many players have suffered reset stats, bugged weapon…

Forza Motorsport‘s Update 6 – due to release in March 2024 – is shaping up to be a huge step forward for the live-service racing game from Turn 10. Notably, the developer has just revealed that the game’s entire Car Level progression mechanic will be getting upended in accordance with player feedback. Notably, Turn 10 has gone back to the drawing board with Forza Motorsport‘s Car Level mechanic, as promised earlier this year. From the very start, a vocal portion of the player base has been highly critical of Turn 10’s…

Recent research has shown that baricitinib, a drug for rheumatoid arthritis, can effectively slow the progression of type 1 diabetes, potentially revolutionizing its management by reducing the need for insulin therapy.A new study reveals that a commonly prescribed rheumatoid arthritis drug may also suppress the development of type 1 diabetes.Researchers at St Vincent’s Institute of Medical Research (SVI) in Melbourne have found that a drug typically used for rheumatoid arthritis can also slow down the development of type…

A world-first clinical trial has found that baricitinib, a drug commonly prescribed for rheumatoid arthritis, preserved the pancreatic cells’ ability to produce their own insulin and slowed the progression of type 1 diabetes in those recently diagnosed with the condition. The drug shows promise as the first disease-modifying treatment for type 1 diabetes that can be given as a tablet.Type 1 diabetes occurs when the body’s immune system attacks and destroys the pancreas’ insulin-secreting cells. However, because the…

Research published this week describes a promising start to using stem cell therapy for multiple sclerosis. In a small Phase I trial, patients who had stem cells directly injected into their brain appeared to tolerate it well and experienced no serious adverse effects. The treatment may have also stopped or slowed the progression of their symptoms, the scientists say, but larger studies will be needed to confirm its effectiveness.“Even AI Rappers are Harassed by Police” | AI UnlockedMultiple sclerosis is an autoimmune…

Multiple sclerosis (MS) is a debilitating disease with few treatment options. But in a new clinical trial, scientists have tested a promising new therapy involving injections of stem cells, which seems to slow progression of the disease.In patients with MS, the immune system begins mistakenly attacking myelin, the tissue that encases and protects nerve fibers. As this sheath sustains more and more damage, it disrupts electrical signals traveling through nerves, resulting in reduced mobility, balance, sensation and muscle…

Researchers have made a significant breakthrough in Parkinson’s disease research. Their study reveals that inhibiting a specific enzyme, USP30, in a mouse model can protect dopamine-producing neurons. This finding halts the disease’s progression and opens the door to new therapeutic possibilities for the 10 million people affected by Parkinson’s worldwide.The findings have the potential to pave the way for new disease-modifying treatments for patients with Parkinson’s disease.A study published in Nature Communications by…

Warcraft Rumble has a…lot going on that hampers the overall player experience, but one late-to-endgame design choice really takes the cake. Make sure you pick up one of each leader if you intend to progress in Warcraft Rumble in any meaningful way. Or, you can stop playing, that’s fine too. Endgame is predicated on having one leader of each type Up until sigil level 75 (sigils essentially serve as your account level/progression marker), the easiest way to progress with the game is to clear every new stage as it is…